Myristoylation of the poliovirus polyprotein is required for proteolytic processing of the capsid and for viral infectivity.

The poliovirus polyprotein is cotranslationally linked to myristic acid at its amino-terminal glycine residue. We investigated the role of myristoylation in the viral replication cycle by site-directed mutagenesis of this glycine codon. Synthetic full-length RNA transcripts carrying a Gly-to-Ala mut...

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Publié dans:	J Virol
Auteurs principaux:	Kräusslich, H G, Hölscher, C, Reuer, Q, Harber, J, Wimmer, E
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1990
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC249411/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2157900/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.5.2433-2436.1990
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