Improved Induction of Antibodies against Key Neutralizing Epitopes by Human Immunodeficiency Virus Type 1 gp120 DNA Prime-Protein Boost Vaccination Compared to gp120 Protein-Only Vaccination

A major challenge in human immunodeficiency virus type 1 (HIV-1) vaccine development is to elicit potent and broadly neutralizing antibodies that are effective against primary viral isolates. Previously, we showed that DNA prime-protein boost vaccination using HIV-1 gp120 antigens was more effective...

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Bibliographic Details
Main Authors: Vaine, Michael, Wang, Shixia, Crooks, Emma T., Jiang, Pengfei, Montefiori, David C., Binley, James, Lu, Shan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493346/
https://ncbi.nlm.nih.gov/pubmed/18495775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00562-08
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