ApoE promotes the proteolytic degradation of Aβ

Apolipoprotein E is associated with age-related risk for Alzheimer’s disease and plays critical roles in Aβ homeostasis. We report that ApoE plays a previously unappreciated role in facilitating the proteolytic clearance of soluble Aβ from the brain. The endolytic degradation of Aβ peptides within m...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jiang, Qingguang, Lee, C.Y. Daniel, Mandrekar, Shweta, Wilkinson, Brandy, Cramer, Paige, Zelcer, Noam, Mann, Karen, Lamb, Bruce, Willson, Timothy M., Collins, Jon L., Richardson, Jill C., Smith, Jonathan D., Comery, Thomas A., Riddell, David, Holtzman, David M., Tontonoz, Peter, Landreth, Gary E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493297/
https://ncbi.nlm.nih.gov/pubmed/18549781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.04.010
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