Mutation of a consensus purine nucleotide binding site in the adeno-associated virus rep gene generates a dominant negative phenotype for DNA replication.
Adeno-associated virus (AAV) contains a multifunctional nonstructural gene, rep, which is required for AAV DNA replication and has pleiotropic effects on positive and negative regulation of gene expression. All of the parvovirus nonstructural genes contain a region of highly conserved amino acid hom...
Enregistré dans:
| Publié dans: | J Virol |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology (ASM)
1990
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC249314/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2157057/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.4.1764-1770.1990 |
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