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Disruption of the homeostatic balance between autoaggressive (CD4(+)CD40(+)) and regulatory (CD4(+)CD25(+)FoxP3(+)) T cells promotes diabetes
Although regulatory T cells (Tregs) are well described, identifying autoaggressive effector T cells has proven more difficult. However, we identified CD4(lo)CD40(+) (Th40) cells as being necessary and sufficient for diabetes in the NOD mouse model. Importantly, these cells are present in pancreata o...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Society for Leukocyte Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2493071/ https://ncbi.nlm.nih.gov/pubmed/18469093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1207857 |
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