Th40 cells (CD4(+)CD40(+) Tcells) drive a more severe form of Experimental Autoimmune Encephalomyelitis than conventional CD4 T cells

CD40-CD154 interaction is critically involved in autoimmune diseases, and CD4 T cells play a dominant role in the Experimental Autoimmune Encephalomyelitis (EAE) model of Multiple Sclerosis (MS). CD4 T cells expressing CD40 (Th40) are pathogenic in type I diabetes but have not been evaluated in EAE....

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Bibliographic Details
Published in:PLoS One
Main Authors: Vaitaitis, Gisela M., Yussman, Martin G., Waid, Dan M., Wagner, David H.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5305068/
https://ncbi.nlm.nih.gov/pubmed/28192476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172037
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