Activation of NOD2 in vivo induces IL-1β production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling

Nucleotide-binding and oligomerization domain 2 (NOD2) belongs to the emerging Nod-like receptor (NLR) family considered important in innate immunity. Mutations in NOD2 cause Blau syndrome, an inherited inflammation of eye, joints, and skin. Mutations in a homologous region of another NLR member, NA...

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Detalhes bibliográficos
Main Authors: Rosenzweig, H. L., Martin, T. M., Planck, S. R., Galster, K., Jann, M. M., Davey, M. P., Kobayashi, K., Flavell, R. A., Rosenbaum, J. T.
Formato: Artigo
Idioma:Inglês
Publicado em: The Society for Leukocyte Biology 2008
Assuntos:
Receptors, Signal Transduction, and Genes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493069/
https://ncbi.nlm.nih.gov/pubmed/18495787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0108015
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