Structural and functional analysis of the Crb2–BRCT(2) domain reveals distinct roles in checkpoint signaling and DNA damage repair

Schizosaccharomyces pombe Crb2 is a checkpoint mediator required for the cellular response to DNA damage. Like human 53BP1 and Saccharomyces cerevisiae Rad9 it contains Tudor(2) and BRCT(2) domains. Crb2-Tudor(2) domain interacts with methylated H4K20 and is required for recruitment to DNA dsDNA bre...

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Autors principals: Kilkenny, Mairi L., Doré, Andrew S., Roe, S. Mark, Nestoras, Konstantinos, Ho, Jenny C.Y., Watts, Felicity Z., Pearl, Laurence H.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2008
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492745/
https://ncbi.nlm.nih.gov/pubmed/18676809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.472808
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