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BRCT Domain Interactions with Phospho-Histone H2A Target Crb2 to Chromatin at Double-Strand Breaks and Maintain the DNA Damage Checkpoint

Relocalization of checkpoint proteins to chromatin flanking DNA double-strand breaks (DSBs) is critical for cellular responses to DNA damage. Schizosaccharomyces pombe Crb2, which mediates Chk1 activation by Rad3(ATR), forms ionizing radiation-induced nuclear foci (IRIF). Crb2 C-terminal BRCT domain...

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Bibliographische Detailangaben
Hauptverfasser: Sofueva, Sevil, Du, Li-Lin, Limbo, Oliver, Williams, Jessica S., Russell, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950532/
https://ncbi.nlm.nih.gov/pubmed/20679485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00413-10
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