Histone H2A Phosphorylation Controls Crb2 Recruitment at DNA Breaks, Maintains Checkpoint Arrest, and Influences DNA Repair in Fission Yeast

Mammalian ATR and ATM checkpoint kinases modulate chromatin structures near DNA breaks by phosphorylating a serine residue in the carboxy-terminal tail SQE motif of histone H2AX. Histone H2A is similarly regulated in Saccharomyces cerevisiae. The phosphorylated forms of H2AX and H2A, known as γ-H2AX...

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Detalhes bibliográficos
Main Authors: Nakamura, Toru M., Du, Li-Lin, Redon, Christophe, Russell, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC434244/
https://ncbi.nlm.nih.gov/pubmed/15226425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.14.6215-6230.2004
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