Tropism-independent protection of macaques against vaginal transmission of three SHIVs by the HIV-1 fusion inhibitor T-1249

We have assessed the potential of the fusion inhibitory peptide T-1249 for development as a vaginal microbicide to prevent HIV-1 sexual transmission. When formulated as a simple gel, T-1249 provided dose-dependent protection to macaques against high-dose challenge with three different SHIVs that use...

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Hlavní autoři: Veazey, Ronald S., Ketas, Thomas A., Klasse, Per Johan, Davison, Donna K., Singletary, Morgan, Green, Linda C., Greenberg, Michael L., Moore, John P.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492474/
https://ncbi.nlm.nih.gov/pubmed/18647836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802666105
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