Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody

To guide vaccine design, we assessed whether human monoclonal antibodies (MAbs) b12 and b6 against the CD4 binding site (CD4bs) on HIV-1 gp120 and F240 against an immundominant epitope on gp41 could prevent vaginal transmission of simian HIV (SHIV)-162P4 to macaques. The two anti-gp120 MAbs have sim...

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Hauptverfasser: Burton, Dennis R., Hessell, Ann J., Keele, Brandon F., Klasse, Per Johan, Ketas, Thomas A., Moldt, Brian, Dunlop, D. Cameron, Poignard, Pascal, Doyle, Lara A., Cavacini, Lisa, Veazey, Ronald S., Moore, John P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131343/
https://ncbi.nlm.nih.gov/pubmed/21690411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1103012108
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