HIV-Induced Type I Interferon and Tryptophan Catabolism Drive T Cell Dysfunction Despite Phenotypic Activation

Infection by the human immunodeficiency virus (HIV) is characterized by functional impairment and chronic activation of T lymphocytes, the causes of which are largely unexplained. We cultured peripheral blood mononuclear cells (PBMC) from HIV-uninfected donors in the presence or absence of HIV. HIV...

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Detalhes bibliográficos
Main Authors: Boasso, Adriano, Hardy, Andrew W., Anderson, Stephanie A., Dolan, Matthew J., Shearer, Gene M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2491901/
https://ncbi.nlm.nih.gov/pubmed/18698365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002961
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