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Evolution of HIV-1 Isolates that Use a Novel Vif-independent Mechanism to Resist Restriction by Human APOBEC3G
The human APOBEC3G protein restricts the replication of Vif-deficient HIV-1 by deaminating nascent viral cDNA cytosines to uracils, leading to viral genomic strand G-to-A hypermutations [1–4]. However, the HIV-1 Vif protein triggers APOBEC3G degradation, helping explain why this innate defense does...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2491687/ https://ncbi.nlm.nih.gov/pubmed/18501607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2008.04.073 |
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