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Conservation and Variability of Dengue Virus Proteins: Implications for Vaccine Design
BACKGROUND: Genetic variation and rapid evolution are hallmarks of RNA viruses, the result of high mutation rates in RNA replication and selection of mutants that enhance viral adaptation, including the escape from host immune responses. Variability is uneven across the genome because mutations resu...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2008
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2491585/ https://ncbi.nlm.nih.gov/pubmed/18698358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0000272 |
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