Conservation and Variability of Dengue Virus Proteins: Implications for Vaccine Design

BACKGROUND: Genetic variation and rapid evolution are hallmarks of RNA viruses, the result of high mutation rates in RNA replication and selection of mutants that enhance viral adaptation, including the escape from host immune responses. Variability is uneven across the genome because mutations resu...

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Detalhes bibliográficos
Main Authors: Khan, Asif M., Miotto, Olivo, Nascimento, Eduardo J. M., Srinivasan, K. N., Heiny, A. T., Zhang, Guang Lan, Marques, E. T., Tan, Tin Wee, Brusic, Vladimir, Salmon, Jerome, August, J. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2491585/
https://ncbi.nlm.nih.gov/pubmed/18698358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0000272
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