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Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors
In earlier work structure-based design studies resulted in the discovery of alkyl substituted diphenyl ether inhibitors of InhA, the enoyl reductase from Mycobacterium tuberculosis. Compounds such as 5-hexyl-2-phenoxyphenol 19 are nM inhibitors of InhA and inhibit the growth of both sensitive and is...
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| Main Authors: | , , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2491328/ https://ncbi.nlm.nih.gov/pubmed/18457948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.04.038 |
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