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Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors

In earlier work structure-based design studies resulted in the discovery of alkyl substituted diphenyl ether inhibitors of InhA, the enoyl reductase from Mycobacterium tuberculosis. Compounds such as 5-hexyl-2-phenoxyphenol 19 are nM inhibitors of InhA and inhibit the growth of both sensitive and is...

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Main Authors: am Ende, Christopher W., Knudson, Susan E., Liu, Nina, Childs, James, Sullivan, Todd J., Boyne, Melissa, Xu, Hua, Gegina, Yelizaveta, Knudson, Dennis L., Johnson, Francis, Peloquin, Charles A., Slayden, Richard A., Tonge, Peter J.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2491328/
https://ncbi.nlm.nih.gov/pubmed/18457948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.04.038
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