Role of c-Abl Kinase in DNA Mismatch Repair-dependent G(2) Cell Cycle Checkpoint Arrest Responses

Current published data suggest that DNA mismatch repair (MMR) triggers prolonged G(2) cell cycle checkpoint arrest after alkylation damage from N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) by activating ATR (ataxia telangiectasia-Rad3-related kinase). However, analyses of isogenic MMR-proficient and...

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Autori principali: Wagner, Mark W., Li, Long Shan, Morales, Julio C., Galindo, Cristi L., Garner, Harold R., Bornmann, William G., Boothman, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
Mechanisms of Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490779/
https://ncbi.nlm.nih.gov/pubmed/18480061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709953200
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