DNA mismatch repair (MMR)-dependent 5-fluorouracil cytotoxicity and the potential for new therapeutic targets

The metabolism and efficacy of 5-fluorouracil (FUra) and other fluorinated pyrimidine (FP) derivatives have been intensively investigated for over fifty years. FUra and its antimetabolites can be incorporated at RNA- and DNA-levels, with RNA level incorporation provoking toxic responses in human nor...

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Main Authors: Li, Long Shan, Morales, Julio C, Veigl, Martina, Sedwick, David, Greer, Sheldon, Meyers, Mark, Wagner, Mark, Fishel, Richard, Boothman, David A
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765589/
https://ncbi.nlm.nih.gov/pubmed/19775280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00423.x
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