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DKK1 Antagonizes Wnt Signaling without Promotion of LRP6 Internalization and Degradation
DKK1 is a secreted protein that antagonizes Wnt signaling and plays essential roles in vertebrate embryogenesis including head induction, skeletal development, and limb patterning. DKK1 is also implicated in osteoporosis, arthritis, and cancer and represents a potential therapeutic target for the tr...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2490777/ https://ncbi.nlm.nih.gov/pubmed/18505732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800014200 |
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