DNA Mismatch Repair-dependent Activation of c-Abl/p73α/GADD45α-mediated Apoptosis

Cells with functional DNA mismatch repair (MMR) stimulate G(2) cell cycle checkpoint arrest and apoptosis in response to N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). MMR-deficient cells fail to detect MNNG-induced DNA damage, resulting in the survival of “mutator” cells. The retrograde (nucleus-to-c...

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Hlavní autoři: Li, Long Shan, Morales, Julio C., Hwang, Arlene, Wagner, Mark W., Boothman, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Mechanisms of Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490771/
https://ncbi.nlm.nih.gov/pubmed/18480060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709954200
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