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DNA Mismatch Repair-dependent Activation of c-Abl/p73α/GADD45α-mediated Apoptosis
Cells with functional DNA mismatch repair (MMR) stimulate G(2) cell cycle checkpoint arrest and apoptosis in response to N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). MMR-deficient cells fail to detect MNNG-induced DNA damage, resulting in the survival of “mutator” cells. The retrograde (nucleus-to-c...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2490771/ https://ncbi.nlm.nih.gov/pubmed/18480060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709954200 |
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