Evidence for covalent attachment of the adeno-associated virus (AAV) rep protein to the ends of the AAV genome.
We have demonstrated that when the covalently joined ends of linear adeno-associated virus (AAV) DNA are resolved in vitro, the virus-encoded Rep protein becomes covalently attached to the 5' ends of the DNA. The covalent bond is between a tyrosine residue of the AAV Rep protein and a 5' phosphate o...
Guardat en:
| Publicat a: | J Virol |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
1990
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC248795/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2173787/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.12.6204-6213.1990 |
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