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Evidence for covalent attachment of the adeno-associated virus (AAV) rep protein to the ends of the AAV genome.

We have demonstrated that when the covalently joined ends of linear adeno-associated virus (AAV) DNA are resolved in vitro, the virus-encoded Rep protein becomes covalently attached to the 5' ends of the DNA. The covalent bond is between a tyrosine residue of the AAV Rep protein and a 5' p...

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Bibliografiske detaljer
Main Authors: Snyder, R O, Im, D S, Muzyczka, N
Format: Artigo
Sprog:Inglês
Udgivet: 1990
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC248795/
https://ncbi.nlm.nih.gov/pubmed/2173787
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