Evidence for covalent attachment of the adeno-associated virus (AAV) rep protein to the ends of the AAV genome.

We have demonstrated that when the covalently joined ends of linear adeno-associated virus (AAV) DNA are resolved in vitro, the virus-encoded Rep protein becomes covalently attached to the 5' ends of the DNA. The covalent bond is between a tyrosine residue of the AAV Rep protein and a 5' phosphate o...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Snyder, R O, Im, D S, Muzyczka, N
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC248795/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2173787/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.12.6204-6213.1990
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