Oncogene-dependent apoptosis is mediated by caspase-9

Understanding how oncogenic transformation sensitizes cells to apoptosis may provide a strategy to kill tumor cells selectively. We previously developed a cell-free system that recapitulates oncogene dependent apoptosis as reflected by activation of caspases, the core of the apoptotic machinery. Her...

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Bibliographic Details
Main Authors: Fearnhead, Howard O., Rodriguez, Joe, Govek, Eve-Ellen, Guo, Wenjun, Kobayashi, Ryuji, Hannon, Greg, Lazebnik, Yuri A.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1998
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC24876/
https://ncbi.nlm.nih.gov/pubmed/9811857
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