Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes

During apoptosis, release of cytochrome c initiates dATP-dependent oligomerization of Apaf-1 and formation of the apoptosome. In a cell-free system, we have addressed the order in which apical and effector caspases, caspases-9 and -3, respectively, are recruited to, activated and retained within the...

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Main Authors: Bratton, Shawn B., Walker, Gail, Srinivasula, Srinivasa M., Sun, Xiao-Ming, Butterworth, Michael, Alnemri, Emad S., Cohen, Gerald M.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2001
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC145489/
https://ncbi.nlm.nih.gov/pubmed/11230124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.5.998
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