Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes

During apoptosis, release of cytochrome c initiates dATP-dependent oligomerization of Apaf-1 and formation of the apoptosome. In a cell-free system, we have addressed the order in which apical and effector caspases, caspases-9 and -3, respectively, are recruited to, activated and retained within the...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Bratton, Shawn B., Walker, Gail, Srinivasula, Srinivasa M., Sun, Xiao-Ming, Butterworth, Michael, Alnemri, Emad S., Cohen, Gerald M.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2001
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145489/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11230124/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.5.998
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