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Oligomerization and activation of caspase-9, induced by Apaf-1 CARD

Apaf-1 facilitates the proteolytic activation of procaspase-9 and maintains the hyperactive state of the processed caspase-9. The underlying molecular mechanisms for these activities remain poorly characterized. Here we report that the isolated Apaf-1 caspase recruitment domain (CARD) forms a large...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Shiozaki, Eric N., Chai, Jijie, Shi, Yigong
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123625/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11904389/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.072544399
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