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Oligomerization and activation of caspase-9, induced by Apaf-1 CARD
Apaf-1 facilitates the proteolytic activation of procaspase-9 and maintains the hyperactive state of the processed caspase-9. The underlying molecular mechanisms for these activities remain poorly characterized. Here we report that the isolated Apaf-1 caspase recruitment domain (CARD) forms a large...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC123625/ https://ncbi.nlm.nih.gov/pubmed/11904389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.072544399 |
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