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Oligomerization and activation of caspase-9, induced by Apaf-1 CARD

Apaf-1 facilitates the proteolytic activation of procaspase-9 and maintains the hyperactive state of the processed caspase-9. The underlying molecular mechanisms for these activities remain poorly characterized. Here we report that the isolated Apaf-1 caspase recruitment domain (CARD) forms a large...

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Autors principals: Shiozaki, Eric N., Chai, Jijie, Shi, Yigong
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC123625/
https://ncbi.nlm.nih.gov/pubmed/11904389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.072544399
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