Effect of Trimethoprim on Macromolecular Synthesis in Escherichia coli

Trimethoprim is a specific inhibitor of dihydrofolate reductase. When added to amino acid supplemented cultures of Escherichia coli, protein, ribonucleic acid (RNA), and deoxyribonucleic acid synthesis are rapidly inhibited. It is shown that thymidylate and purine synthesis must continuously occur i...

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Bibliografske podrobnosti

izdano v:	J Bacteriol
Principais autores:	Miovic, Margaret, Pizer, Lewis I.
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 1971
Teme:	Physiology and Metabolism
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC248708/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4254117/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.106.3.856-862.1971
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