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Effect of Trimethoprim on Macromolecular Synthesis in Escherichia coli

Trimethoprim is a specific inhibitor of dihydrofolate reductase. When added to amino acid supplemented cultures of Escherichia coli, protein, ribonucleic acid (RNA), and deoxyribonucleic acid synthesis are rapidly inhibited. It is shown that thymidylate and purine synthesis must continuously occur i...

Cur síos iomlán

Sábháilte in:
Sonraí bibleagrafaíochta
Foilsithe in:J Bacteriol
Príomhchruthaitheoirí: Miovic, Margaret, Pizer, Lewis I.
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: American Society for Microbiology (ASM) 1971
Ábhair:
Rochtain ar líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC248708/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4254117/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.106.3.856-862.1971
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