Effect of Trimethoprim on Macromolecular Synthesis in Escherichia coli
Trimethoprim is a specific inhibitor of dihydrofolate reductase. When added to amino acid supplemented cultures of Escherichia coli, protein, ribonucleic acid (RNA), and deoxyribonucleic acid synthesis are rapidly inhibited. It is shown that thymidylate and purine synthesis must continuously occur i...
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| Published in: | J Bacteriol |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology (ASM)
1971
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC248708/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4254117/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.106.3.856-862.1971 |
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