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Effect of Trimethoprim on Macromolecular Synthesis in Escherichia coli

Trimethoprim is a specific inhibitor of dihydrofolate reductase. When added to amino acid supplemented cultures of Escherichia coli, protein, ribonucleic acid (RNA), and deoxyribonucleic acid synthesis are rapidly inhibited. It is shown that thymidylate and purine synthesis must continuously occur i...

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Bibliografski detalji
Glavni autori: Miovic, Margaret, Pizer, Lewis I.
Format: Artigo
Jezik:Inglês
Izdano: 1971
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC248708/
https://ncbi.nlm.nih.gov/pubmed/4254117
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