Identification and Structural Characterization of a CBP/p300-Binding Domain from the ETS Family Transcription Factor GABPα

Using NMR spectroscopy we identified and characterized a previously unrecognized structured domain near the N-terminus (residues 35−121) of the ETS family transcription factor GABPα. The monomeric domain folds as a 5-stranded β-sheet crossed by a distorted helix. Although globally resembling ubiquit...

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Main Authors: Kang, Hyun-Seo, Nelson, Mary L., Mackereth, Cameron D., Schärpf, Manuela, Graves, Barbara J., McIntosh, Lawrence P.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2486348/
https://ncbi.nlm.nih.gov/pubmed/18295234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.01.054
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