Double-strand break damage and associated DNA repair genes predispose smokers to gene methylation

Gene promoter hypermethylation in sputum is a promising biomarker for predicting lung cancer. Identifying factors that predispose smokers to methylation of multiple gene promoters in the lung could impact strategies for early detection and chemoprevention. This study evaluated the hypothesis that do...

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Hauptverfasser: Leng, Shuguang, Stidley, Christine A., Willink, Randy, Bernauer, Amanda, Do, Kieu, Picchi, Maria A., Sheng, Xin, Frasco, Melissa, A., Berg, David Van Den, Gilliland, Frank D., Zima, Christopher, Crowell, Richard E., Belinsky, Steven A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483467/
https://ncbi.nlm.nih.gov/pubmed/18413776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-6344
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