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Src family kinase mediated negative regulation of hematopoietic stem cell mobilization involves both intrinsic and microenvironmental factors

OBJECTIVE: The intracellular signals that contribute to G-CSF receptor induced stem cell mobilization are poorly characterized. METHODS: We show enhanced G-CSF induced mobilization of stem cells in mice deficient in the expression of Src family kinases (SFK−/−), which is associated with hypersensiti...

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Bibliografiske detaljer
Main Authors: Borneo, Jovencio, Munugalavadla, Veerendra, Sims, Emily Catherine, Vemula, Sasidhar, Orschell, Christie M., Yoder, Merv, Kapur, Reuben
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481405/
https://ncbi.nlm.nih.gov/pubmed/17588471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2007.03.017
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