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Flavin-dependent thymidylate synthase X limits chromosomal DNA replication
We have investigated the hitherto unexplored possibility that differences in the catalytic efficiencies of thymidylate synthases ThyX and ThyA, enzymes that produce the essential DNA precursor dTMP, have influenced prokaryotic genome evolution. We demonstrate that DNA replication speed in bacteria a...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2481370/ https://ncbi.nlm.nih.gov/pubmed/18621705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801356105 |
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