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Distinct conformational changes in β-arrestin report biased agonism at seven-transmembrane receptors
β-arrestins critically regulate G protein-coupled receptors (GPCRs), also known as seven-transmembrane receptors (7TMRs), both by inhibiting classical G protein signaling and by initiating distinct β-arrestin-mediated signaling. The recent discovery of β-arrestin-biased ligands and receptor mutants...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2481318/ https://ncbi.nlm.nih.gov/pubmed/18621717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804246105 |
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