Distinct conformational changes in β-arrestin report biased agonism at seven-transmembrane receptors

β-arrestins critically regulate G protein-coupled receptors (GPCRs), also known as seven-transmembrane receptors (7TMRs), both by inhibiting classical G protein signaling and by initiating distinct β-arrestin-mediated signaling. The recent discovery of β-arrestin-biased ligands and receptor mutants...

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Bibliographic Details
Main Authors: Shukla, Arun K., Violin, Jonathan D., Whalen, Erin J., Gesty-Palmer, Diane, Shenoy, Sudha K., Lefkowitz, Robert J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481318/
https://ncbi.nlm.nih.gov/pubmed/18621717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804246105
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