Stress-Induced p38 Mitogen-Activated Protein Kinase Activation Mediates κ-Opioid-Dependent Dysphoria

The molecular mechanisms mediating stress-induced dysphoria in humans and conditioned place aversion in rodents are unknown. Here, we show that repeated swim stress caused activation of both κ-opioid receptor (KOR) and p38 mitogen-activated protein kinase (MAPK) coexpressed in GABAergic neurons in t...

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Detalhes bibliográficos
Main Authors: Bruchas, Michael R., Land, Benjamin B., Aita, Megumi, Xu, Mei, Barot, Sabiha K., Li, Shuang, Chavkin, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481272/
https://ncbi.nlm.nih.gov/pubmed/17959804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3769-07.2007
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