Mapping of mutations associated with neurovirulence in monkeys infected with Sabin 1 poliovirus revertants selected at high temperature.

Poliovirus type 1 neurovirulence is difficult to analyze because of the 56 mutations which differentiate the neurovirulent Mahoney strain from the attenuated Sabin strain. We have isolated four neurovirulent mutants which differ from the temperature-sensitive parental Sabin 1 strain by only a few mu...

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Detalles Bibliográficos

Publicado en:	J Virol
Principais autores:	Christodoulou, C, Colbere-Garapin, F, Macadam, A, Taffs, L F, Marsden, S, Minor, P, Horaud, F
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1990
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC247983/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2168976/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.64.10.4922-4929.1990
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