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A mutation in the RNA polymerase of poliovirus type 1 contributes to attenuation in mice.

The attenuated Sabin strain of poliovirus type 1 (PV-1) differs from the neurovirulent PV-1 Mahoney strain by 55 nucleotide mutations. Only one of these mutations (A-480-->G, in the 5' noncoding (5' NC) region of the genome, is well characterized, and it confers a strong attenuating eff...

詳細記述

保存先:
書誌詳細
主要な著者: Tardy-Panit, M, Blondel, B, Martin, A, Tekaia, F, Horaud, F, Delpeyroux, F
フォーマット: Artigo
言語:Inglês
出版事項: 1993
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC237848/
https://ncbi.nlm.nih.gov/pubmed/8392604
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