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A mutation in the RNA polymerase of poliovirus type 1 contributes to attenuation in mice.

The attenuated Sabin strain of poliovirus type 1 (PV-1) differs from the neurovirulent PV-1 Mahoney strain by 55 nucleotide mutations. Only one of these mutations (A-480-->G, in the 5' noncoding (5' NC) region of the genome, is well characterized, and it confers a strong attenuating eff...

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Detaylı Bibliyografya
Asıl Yazarlar: Tardy-Panit, M, Blondel, B, Martin, A, Tekaia, F, Horaud, F, Delpeyroux, F
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1993
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC237848/
https://ncbi.nlm.nih.gov/pubmed/8392604
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