A mutation in the RNA polymerase of poliovirus type 1 contributes to attenuation in mice.

The attenuated Sabin strain of poliovirus type 1 (PV-1) differs from the neurovirulent PV-1 Mahoney strain by 55 nucleotide mutations. Only one of these mutations (A-480-->G, in the 5' noncoding (5' NC) region of the genome, is well characterized, and it confers a strong attenuating effect. We attem...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Tardy-Panit, M, Blondel, B, Martin, A, Tekaia, F, Horaud, F, Delpeyroux, F
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1993
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237848/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8392604/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.8.4630-4638.1993
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