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The deletion of 41 proximal nucleotides reverts a poliovirus mutant containing a temperature-sensitive lesion in the 5' noncoding region of genomic RNA.

We generated a number of small deletions and insertions in the 5' noncoding region of an infectious cDNA copy of the poliovirus RNA genome. Transfection of these mutated cDNAs into COS-1 cells produced the following phenotypic categories: (i) wild-type mutations, (ii) lethal mutations, (iii) mu...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Dildine, S L, Semler, B L
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1989
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC247759/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2536107/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.63.2.847-862.1989
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