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Determinants in the 5' noncoding region of poliovirus Sabin 1 RNA that influence the attenuation phenotype.

A number of recombinants between the virulent Mahoney and attenuated Sabin strains of type 1 poliovirus were constructed by using infectious cDNA clones of the two strains. To identify a strong neurovirulence determinant(s) residing in the genome region upstream of nucleotide position 1122, these re...

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Autors principals: Kawamura, N, Kohara, M, Abe, S, Komatsu, T, Tago, K, Arita, M, Nomoto, A
Format: Artigo
Idioma:Inglês
Publicat: 1989
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC247827/
https://ncbi.nlm.nih.gov/pubmed/2536835
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