RNA sequence variants in live poliovirus vaccine and their relation to neurovirulence.

Mutant analysis by polymerase chain reaction and restriction enzyme cleavage (MAPREC) was used to study sequence heterogeneity and stability in attenuated poliovirus type 3 at positions in which the vaccine virus differs from its wild-type progenitor. Of seven genomic positions tested, only two (pos...

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Библиографические подробности
Главные авторы: Chumakov, K M, Norwood, L P, Parker, M L, Dragunsky, E M, Ran, Y X, Levenbook, I S
Формат: Artigo
Язык:Inglês
Опубликовано: 1992
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC240798/
https://ncbi.nlm.nih.gov/pubmed/1309923
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