RNA sequence variants in live poliovirus vaccine and their relation to neurovirulence.

Mutant analysis by polymerase chain reaction and restriction enzyme cleavage (MAPREC) was used to study sequence heterogeneity and stability in attenuated poliovirus type 3 at positions in which the vaccine virus differs from its wild-type progenitor. Of seven genomic positions tested, only two (pos...

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Hlavní autoři: Chumakov, K M, Norwood, L P, Parker, M L, Dragunsky, E M, Ran, Y X, Levenbook, I S
Médium: Artigo
Jazyk:Inglês
Vydáno: 1992
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC240798/
https://ncbi.nlm.nih.gov/pubmed/1309923
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