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RNA sequence variants in live poliovirus vaccine and their relation to neurovirulence.

Mutant analysis by polymerase chain reaction and restriction enzyme cleavage (MAPREC) was used to study sequence heterogeneity and stability in attenuated poliovirus type 3 at positions in which the vaccine virus differs from its wild-type progenitor. Of seven genomic positions tested, only two (pos...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Chumakov, K M, Norwood, L P, Parker, M L, Dragunsky, E M, Ran, Y X, Levenbook, I S
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 1992
Schlagworte:
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240798/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1309923/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.2.966-970.1992
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