Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency.

Using nonsense and deletion mutants of herpes simplex virus type 1, we investigated the roles of three immediate-early proteins (ICP4, ICP27 and ICP0) in the establishment and reactivation of ganglionic latency in a mouse ocular model. DNA hybridization, superinfection-rescue, and cocultivation tech...

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Bibliographic Details
Main Authors: Leib, D A, Coen, D M, Bogard, C L, Hicks, K A, Yager, D R, Knipe, D M, Tyler, K L, Schaffer, P A
Format: Artigo
Language:Inglês
Published: 1989
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC247748/
https://ncbi.nlm.nih.gov/pubmed/2536101
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